Vincenzo Tombolini Selected Research

Embryonal Rhabdomyosarcoma

1/2019	PARP inhibitors affect growth, survival and radiation susceptibility of human alveolar and embryonal rhabdomyosarcoma cell lines.
10/2017	Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells.
2/2016	Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population.
1/2011	MEK/ERK inhibitor U0126 increases the radiosensitivity of rhabdomyosarcoma cells in vitro and in vivo by downregulating growth and DNA repair signals.

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Vincenzo Tombolini Research Topics

Disease

63	Neoplasms (Cancer) 02/2023 - 02/2003
27	Prostatic Neoplasms (Prostate Cancer) 08/2023 - 05/2008
26	Rectal Neoplasms (Rectal Cancer) 02/2023 - 01/2013
15	Squamous Cell Carcinoma of Head and Neck 05/2024 - 05/2006
15	Head and Neck Neoplasms (Head and Neck Cancer) 08/2022 - 10/2015
12	Carcinoma (Carcinomatosis) 09/2022 - 01/2004
10	Neoplasm Metastasis (Metastasis) 08/2023 - 12/2013
10	Glioblastoma (Glioblastoma Multiforme) 01/2020 - 05/2006
9	Rhabdomyosarcoma 10/2021 - 01/2011
8	Breast Neoplasms (Breast Cancer) 09/2022 - 01/2010
8	Ovarian Neoplasms (Ovarian Cancer) 06/2021 - 12/2014
6	Pain (Aches) 01/2023 - 04/2005
6	Adenocarcinoma 10/2019 - 05/2004
5	COVID-19 01/2023 - 01/2020
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 08/2022 - 05/2003
4	Anal Canal Carcinoma 07/2019 - 01/2014
4	Embryonal Rhabdomyosarcoma 01/2019 - 01/2011
4	B-Cell Lymphoma (Lymphoma, B Cell) 12/2018 - 10/2017
3	Oropharyngeal Neoplasms 12/2022 - 12/2016
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2022 - 01/2010
3	Sarcoma (Soft Tissue Sarcoma) 01/2020 - 01/2019
3	Carcinogenesis 12/2019 - 01/2014
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2023 - 09/2022
2	Brain Neoplasms (Brain Tumor) 09/2022 - 12/2014
2	Xerostomia 01/2022 - 03/2020
2	Infections 07/2021 - 01/2020
2	Endometrial Neoplasms (Endometrial Cancer) 04/2020 - 01/2017
2	Osteoradionecrosis 01/2020 - 11/2016
2	Pancreatic Neoplasms (Pancreatic Cancer) 10/2019 - 09/2014
2	Astrocytoma (Pilocytic Astrocytoma) 06/2012 - 07/2006
1	Squamous Cell Neoplasms (Squamous Cell Cancer) 05/2024
1	Frailty 09/2022

Drug/Important Bio-Agent (IBA)

9	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 02/2003
8	Hormones (Hormone)IBA 02/2016 - 08/2010
7	AndrogensIBA 09/2016 - 05/2008
6	Oxaliplatin (Eloxatin)FDA LinkGeneric 12/2019 - 05/2013
6	Temozolomide (Temodar)FDA LinkGeneric 09/2019 - 05/2006
6	Androgen Receptors (Androgen Receptor)IBA 06/2013 - 10/2009
5	Cisplatin (Platino)FDA LinkGeneric 06/2022 - 05/2006
5	Proteins (Proteins, Gene)FDA Link 01/2021 - 02/2003
4	Cetuximab (Erbitux)FDA Link 05/2024 - 03/2016
4	Histone Deacetylase InhibitorsIBA 10/2021 - 03/2012
4	Phosphotransferases (Kinase)IBA 01/2020 - 01/2011
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 09/2018 - 01/2011
4	bicalutamide (Casodex)FDA LinkGeneric 12/2011 - 05/2008
3	PlatinumIBA 05/2024 - 04/2019
3	belinostatIBA 10/2019 - 03/2012
3	MethyltransferasesIBA 09/2019 - 11/2010
3	Biomarkers (Surrogate Marker)IBA 05/2019 - 04/2015
3	U 0126 (UO 126)IBA 09/2018 - 01/2011
3	Docetaxel (Taxotere)FDA Link 08/2011 - 05/2006
2	Monoclonal AntibodiesIBA 05/2024 - 12/2021
2	Trinitrotoluene (TNT)IBA 02/2023 - 02/2022
2	Tyrosine Kinase InhibitorsIBA 09/2022 - 10/2009
2	SolutionsIBA 08/2022 - 01/2017
2	Amylases FDA Link 01/2022 - 10/2017
2	OTX015IBA 03/2021 - 01/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2020 - 04/2019
2	Erythropoietin FDA Link 01/2020 - 10/2017
2	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2020 - 01/2014
2	EphrinsIBA 01/2020 - 10/2017
2	AntioxidantsIBA 01/2020 - 04/2019
2	givinostat hydrochlorideIBA 01/2019 - 01/2019
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2019 - 01/2017
2	givinostatIBA 01/2019 - 01/2019
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2019 - 01/2017
2	Leucovorin (Folinic Acid)FDA Link 09/2018 - 12/2017
2	Cyclin D1IBA 09/2016 - 02/2016
2	Analgesics (Analgesic Drugs)IBA 01/2015 - 04/2005
2	Prostate-Specific Antigen (Semenogelase)IBA 12/2014 - 01/2014
2	palomid 529IBA 06/2014 - 08/2011
2	Mechanistic Target of Rapamycin Complex 2IBA 06/2014 - 08/2011
2	Mechanistic Target of Rapamycin Complex 1IBA 06/2014 - 08/2011
2	Erlotinib Hydrochloride (CP 358,774)FDA Link 10/2011 - 10/2009
2	Ifosfamide FDA LinkGeneric 05/2008 - 05/2006
1	NivolumabIBA 10/2022
1	AfatinibIBA 09/2022

Therapy/Procedure

80	Radiotherapy 05/2024 - 05/2003
26	Chemoradiotherapy 05/2024 - 05/2004
25	Drug Therapy (Chemotherapy) 05/2024 - 05/2003
24	Therapeutics 02/2023 - 04/2005
24	Neoadjuvant Therapy 02/2023 - 05/2004
9	Induction Chemotherapy 06/2021 - 12/2014
8	Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated) 05/2024 - 07/2014
6	Immunotherapy 10/2022 - 05/2008
5	Adjuvant Radiotherapy 12/2019 - 07/2005
4	Palliative Care (Palliative Therapy) 08/2023 - 04/2005
4	Brachytherapy 03/2023 - 01/2017
4	Adjuvant Chemoradiotherapy 11/2021 - 12/2014
4	Castration 06/2013 - 10/2009
3	Adjuvant Chemotherapy 05/2021 - 06/2016
3	Prostatectomy (Retropubic Prostatectomy) 07/2018 - 06/2013
2	Aftercare (After-Treatment) 03/2020 - 01/2015
2	Neck Dissection (Radical Neck Dissection) 03/2016 - 12/2013
2	Cryosurgery 03/2016 - 01/2015
2	Mastectomy (Mammectomy) 12/2015 - 09/2015
2	Salvage Therapy 01/2014 - 12/2012
2	Combined Modality Therapy 01/2014 - 01/2011
1	Ultrasonic Surgical Procedures 01/2023
1	Prostheses and Implants (Prosthesis) 08/2022